Mucocutaneous hyperpigmentation

Hyperpigmentation and chikungunya fever*

Diffuse mucocutaneous leishmaniasis.

Fig. 1 : Pappulonodular lesions over the face Fig. 2: Pappulonodular lesions over the tongue and soft palate Fig. 3: Smear biopsy of the skin lesion showing multiple amastigotes of Leishmania tropica intracellularly A 27 year old Hindu male, resident of district Barmer, Rajasthan , presented with multiple, diffuse, brownish, non umbilicated, papulonodular, non itchy, swellings of size 2 22 mm a...

Bleomycin-induced flagellate hyperpigmentation.

Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.

Flagellate hyperpigmentation from bleomycin.

Sir, Mucocutaneous side effects associated with bleomycin are stomatitis, ulcers, scaly erythematous and bullous lesions, sclerosis, nail changes, digital gangrene and pigmentary alterations. Hyperpigmentation occurring mainly on the pressure areas of the skin as well as in areas of scratch marks is seen in approximately 30% of patients. Flagellate hyperpigmentation is very characteristic of bl...

Tegafur-induced acral hyperpigmentation

Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse...